I am married to a Singapore Citizen and also hold an Employment Pass in Singapore. Should I use my spouse’s Singpass or my own to access the e-PR system?

It depends on the type of scheme you are applying under.

As a spouse of a Singapore Citizen, you can apply under the Family Ties scheme. In this scenario, your spouse’s Singpass will be used.

However, you can also apply on your own under the PTS scheme as an EP holder. In this scenario, you can use your Singapass.

Which route to take, depends on your specific circumstances.