If my E Pass or S Pass gets terminated, would it affect my PR application?

Applicants who apply under the PTS scheme must have a valid S Pass or Employment Pass at the time of application as well as at the time of completion of formalities. Any PTS applicant without a proper work pass will automatically get rejected.

If you have applied for PR while on a valid pass, and then if the pass expires (job loss etc) then your PR application will get invalidated.